Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.

The proton-sensing GPCRs detect extracellular low pH and regulate ... and G protein coupling cooperate to regulate APJR signaling pathway, providing insight for drug discovery.

GPCR Therapeutics plans to successfully finalize ... presents an alternative signaling pathway that is synergistically dependent on the activation of both CXCR4 and B2AR. Morningstar Research ...

Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity.