Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

In a paper published in SCIENCE CHINA Life Science, an international team of scientists provided a comprehensive overview of ...

An AI foundation model capable of predicting gene activity across many different human cell types may expedite research for genetic disorders, cancer, and complex diseases.

ASH 2024 Highlights: Bispecifics in Combination Therapies for B-Cell Lymphomas EP: 6 . MAIC Analyses and Bispecific Therapies: Guiding Treatment Decisions in B-Cell Lymphomas ...

Flow is a 2024 animated fantasy adventure directed by Latvian filmmaker Gints Zilbalodis. The film debuted in Los Angeles and New York on November 22, 2024, followed by a wider U.S. release on ...

Flow—a critically acclaimed animated movie about a cat’s survival during a massive flood—arrives on digital streaming this week. Flow opened in theaters in limited release in theaters on Nov ...

3) Collect a single-cell per well into 96 or 384-well plates containing RNA extraction buffer for single-cell sequencing. The plate must be spun ... good condition for further manipulation. Although ...

Share on Pinterest Do all our cells have a type of memory, and if so, how might this influence health? We investigate. Design by MNT; Photography by Grant Faint/Getty Images & Ed Reschke/Getty Images.

If protein or DNA molecules from the sample pass through the pore, this reduces the flow of ions that can pass ... Proteins perform essential roles in cells, and even slight changes in their ...

Despite advancements in therapeutic interventions and an enhanced understanding of its pathophysiology, emerging techniques such as single-cell RNA sequencing (scRNA-seq) and Mendelian randomization ...