These cytokines also mediate damage to hepatocyte bile transport system (NTCP; OATP; BSEP; MRP2), which disrupts tight junctions and limits intracellular biotransformation, leading to bile metabolism ...

and apical sodium bile acid (also known as ileal bile acid transport) inhibitor (elobixibat). The numbers needed to treat (NNT), estimated from placebo-controlled clinical trials comparing these ...

Fat metabolism is a fascinating process and essential for human survival. It involves the digestion, absorption, transportation and utilization of lipids as a source of energy or as an energy reserve.

FGF19 negatively regulates bile acid synthesis and recombinant FGF19 increases the metabolic rate of mice. Unfortunately, FGF19 transgenic mice develop hepatocellular carcinomas, and this side ...

Jan. 28, 2025 — A 'pocket' on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ... First Mouse With Two Male Parents to Reach Adulthood ...

The standard treatment for HoFH is LDL apheresis combined with maximum tolerated potent statins, ezetimibe and bile acid sequestrants. In untreated HoFH, coronary heart disease usually develops in ...

Clin Lipidology. 2012;7(4):363-365. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

Gallstone disease is the most common disorder affecting the biliary system, the body's system of transporting bile. Gallstones are solid, pebble-like masses that form in the gallbladder or the biliary ...