In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Accumulation of CD11c + proinflammatory adipose tissue macrophages (ATM) is an important driver of vAT inflammation. We investigated the role of ATMs in hepatic inflammation during NASH development.
The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...
The study was published in the journal JCI Insight. Macrophages are immune cells that reside in and protect the lungs and are also recruited to the lungs in high numbers during injury or disease ...
Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses. Corrigendum to "Engineering bispecific T-cell engagers to deplete ...
Macrophage composition in white adipose tissue is believed ... and BV605 CD14 (Cat# 301834) from Biolegend and PE-Cy5.5 CD11c (Cat# MHCD11c18) from Life Technologies. The backbone staining was ...
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