C&EN23d
Discovery of Spirosnuolides A–D, Type I/III Hybrid Polyketide Spiro-Macrolides for a Chemotherapeutic Lead against Lung Cancer
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea ...
Frontiers1mon
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment
Changes in amino acid levels can affect both mTORC1 and mTORC2 levels. Moreover, PI3K/Akt axis is considered as the upstream regulator of mTORC1. Therefore, most of the molecular pathways are related ...
eLife1mon
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer
This article uncovers a new important role of STAMBPL1 in promoting angiogenesis in triple-negative breast cancer (TNBC) and elucidates the specific mechanisms by which it activates the ...