Stockhouse15d
Aptose Signs CRADA with NCI to Develop Tuspetinib for AML and MDS in Newly Launched MyeloMATCH Precision Medicine Trials
Tuspetinib selected for a prestigious national clinical research program for ability to target broad spectrum of AML and MDS populations Trials to test tuspetinib in targeted drug combinations for ...
Frontiers28d
Prediction of acute myeloid leukemia prognosis based on autophagy features and characterization of its immune microenvironment
Background: Autophagy promotes the survival of acute myeloid leukemia (AML) cells by removing damaged organelles and proteins and protecting them from stress-induced apoptosis. Although many studies ...
Frontiers1mon
Targeting autophagy: polydatin’s role in inducing cell death in AML
Drawing on the aforementioned research foundation, the primary objective of this study is to explore the therapeutic efficacy of PD in the treatment of AML and elucidate the precise mechanism ...
eLife7y
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy
We uncovered an essential role for autophagy in T-tubule remodeling with genetic screens of a developmentally regulated remodeling program in Drosophila abdominal muscles. Here, we show that autophagy ...