TOR signalling has key roles in cancer and autophagy. This study describes a ... provide evidence supporting the spatial separation of mTORC1 activation and signalling. Differentially localized ...

Autophagy, frequently referred to as the self-recycling process ... There are two complexes including mTORC1 comprised of Raptor, Deptor, mTOR, mLST8 and PRAS40, and mTORC2 comprised of Rictor, Deptor ...

EMPA can reduce glycolysis by directly binding Glucose transporter 1 (GLUT1), and attenuate cardiac remodeling induced by pressure overload by increasing AMPK activity and reducing mTORC1 expression .

The mTOR complex 1 (mechanistic Target of Rapamycin complex 1, in short ‘mTORC1’) is the central component of a protein network that senses whether a cell has access to sufficient nutrients. Therefore ...

Studies in mouse embryos and human gastruloids have shown that aneuploid cells show proteotoxic stress, autophagy and p53 activation and that they are eliminated from the epiblast by apoptosis while ...

Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, ...

This study presents valuable findings related to seasonal brain size plasticity in the Eurasian common shrew (Sorex araneus), which is an excellent model system for these studies. The evidence ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Once exported from the nucleus to the ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China ...

cEpilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, MA, USA dDepartment of Neurology, Harvard Medical School, Boston, MA, USA ...