A needle aspiration of a subcutaneous tophus located on the palmar aspect of the left forefinger allowed demonstration of needle-shaped, negatively birefringent monosodium urate (MSU) crystals by ...

A type of arthritis caused when uric acid crystals get lodged in joints, causing extreme inflammation and pain Kidney stones: Most specifically a type called a urate stone caused by the accumulation ...

Gout flares among adults in the United States are significantly underreported to healthcare providers, with nearly 72% of flares either not reported or pretreated/prevented by patients, according to ...

A novel statistical framework and approach using sibling phenotype pairs allows inference of genetic architecture in the tails of complex traits to be made without genetic data.

The current strategy for managing chronic gout is the use of uric-acid-lowering drugs to reduce urate production or of a uricosuric agent to promote renal uric acid excretion. Probenecid is ...

Peroxynitrite induces cell death, and can influence signal-transduction processes, mitochondrial function and signalling of apoptosis. The formation and reactions of peroxynitrite play a ...

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