Paige’s Butterfly Run presents a $215,000 donation to the Upstate Foundation. Those involved in the Dec. 20 presentation were (from left to right): Dr. Melanie Comito, Toni Gary, and Chris Arnold, ...

Friday's highly anticipated weather event is finally here, with Upstate residents stepping outside their homes to take in the region's first snowfall in three years. Although snowfall is projected ...

THE WYFF4.COM MOBILE APP. MOVING ON TO SOME BREAKING NEWS IN SPARTANBURG COUNTY. NOW, THE CORONER’S OFFICE SAYS A PEDESTRIAN IS DEAD AFTER A CRASH. TROOPERS SAY THIS WAS AROUND 630 LAST NIGHT ON ...

Snow arrived in the Upstate area of South Carolina Friday morning before turning into nasty problematic freezing rain.(Live coverage above when we are on the air)The snow picked up intensity ...

SPARTANBURG, S.C. (AP) Truth Harris scored 18 points as Radford beat South Carolina Upstate 80-67 on Saturday. Harris added six rebounds and three steals for the Highlanders (12-6, 2-1 Big South ...

Emergency department staff and medical students assess the new portable ultrasound machines at Upstate University Hospital. PHOTO CREDIT: UPSTATE MEDICAL UNIVERSITY WEBSITE SYRACUSE — Upstate ...

Syracuse will have a new quarterback in 2025 as Kyle McCord will not return and has declared for the NFL Draft. Syracuse quarterback Kyle McCord will not return to the Orange for the 2025 season ...

Syracuse football has secured another commitment in the 2026 recruiting class. Class of 2026 Camden (NJ) High offensive lineman Jojo White announced his commitment to the Orange Sunday evening on ...

Clinicians have successfully used custom-made 3D printed bone scaffolds, printed on-site at The University of Queensland, to rebuild part of a man's jawbone.

Kyle McCord’s time at Syracuse may have been short-lived but it sure was memorable. On Friday, the former St. Joseph’s Prep quarterback announced he has declared for the NFL draft following one season ...