2017). E3 ubiquitin ligases are critical components of the ubiquitin-proteasome system (UPS), responsible for ubiquitination and subsequent degradation of target proteins. PROTACs that exploit ...

In terms of the key targets in cuproptosis metabolic pathways, they can be categorized into three types: oxidative stress, mitochondrial respiration, ubiquitin-proteasome system ... trigger UPS ...

Nov. 23 (UPI) --The world's largest courier service, UPS, will pay $45 million in fines after settling claims one of its units misrepresented earnings, the U.S. Securities and Exchange Commission ...

(Lt. Amy Forsythe/U.S. Navy) WARSAW, Poland — In a major step towards ramping up NATO’s missile-defense capabilities, the alliance took control of the Aegis Ashore Missile Defence System ...

The split intein-mediated protein ligation (SIMPL) system for detecting protein-protein interactions has been enhanced by ...

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Dec. 9, 2024 — Astronomers have found a way to spot the smallest, 'decameter,' asteroids within the main asteroid belt. They used their approach to detect more than 100 new asteroids, ranging ...