The α-tubulin and β-tubulin monomers of the protofilaments ... arrangement of protofilaments and consequently impair the functions of MTs. The study also explored MT interactions with Taxol ...

MTs are composed of α-tubulin and β-tubulin proteins ... revealing potential for advancing drug discovery. Understanding MT function and protein interactions can guide the development of ...

Therefore, single XMAP215 molecules appear to 'tip-track' the plus end of the growing microtubule. ...XMAP215 functions as a processive polymerase ...

This paper presents the important discovery that lipid metabolic imbalance caused by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells.

ALE.P02 has a potentially first-in-class tubulin inhibitor payload ... that aims to restore the function of the protein UNC13A, which is thought to play a role in 97% of genetic and sporadic ...

α-tubulin was used as loading control ... Interaction between Lymphocyte Function-Associated Antigen 1 (LFA-1) and its ligand Intercellular Adhesion Molecule 1 (ICAM-1) has been reported to drive T ...

GAPDH, actin, or β-tubulin (Proteintech, China) was used as an internal reference band. All experimental procedures were repeated thrice. The forelimb placement test was conducted to evaluate ...

First, concomitant chemoradiotherapy can be used with organ-preserving intent, resulting in improved cosmesis and function compared with surgical resection with or without adjuvant treatment.

However, there are no therapies that directly treat the primary feature of the disease. This is due in part to the complexity of normal diastolic function, and the challenge of isolating the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The identification of pathways that control ...