Eye movements may also be abnormal in IMDs including external ophthalmoplegia in mitochondrial cytopathies ... In the late infantile/juvenile forms of Niemann–Pick type C, vertical supranuclear gaze ...

More information: Miriam Scarpa et al, Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients' brains, Alzheimer's & Dementia (2024). DOI: 10.1002/alz.14409 ...

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are sporadic four-repeat tauopathies that have characteristic clinical and neuropathologic profiles, but also share ...

Fasudil is under clinical development by Woolsey Pharmaceuticals and currently in Phase II for Progressive Supranuclear Palsy. According to GlobalData, Phase II drugs for Progressive Supranuclear ...

Internuclear ophthalmoplegia is common in MS and results from damage to interneurons travelling from the cranial nerve (CN) VI nucleus in the pons to the contralateral medial rectus subnucleus of ...

These features, atypical of progressive supranuclear palsy, suggested the diagnosis of Whipple’s disease, which was subsequently confirmed by polymerase chain reaction analysis of intestinal biopsy ...

Progressive supranuclear palsy (PSP) is a severe and rapidly progressing neurodegenerative disease that affects both motor and cognitive functions. Often misdiagnosed or underdiagnosed due to a lack ...

Censavudine is under clinical development by Transposon Therapeutics and currently in Phase II for Progressive Supranuclear Palsy. According to GlobalData, Phase II drugs for Progressive Supranuclear ...

such as early autonomic disturbance and pyramidal signs exhibited by patients with multiple system atrophy (MSA), supranuclear gaze palsy and frontal/dysexecutive syndrome by those with progressive ...