Discovery of enzyme pathway may lead to lifesaving leishmaniasis treatments
A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...
Hosted on MSN4mon
Understanding Yeast Membrane Microdomains with Cryo-EM
The plasma membrane has distinct regions called ... the main sterol in yeast cells. Sterols modulate membrane fluidity and permeability and are often associated with membrane microdomains.
News Medical on MSN4d
Research points the way to lifesaving antiparasitic drugs while unlocking a scientific mystery
A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...
Drexel University3mon
Mechanism of Cholesterol-Induced Impairment of Store-Operated Calcium Entry in Endothelial Cells
Elevated plasma membrane cholesterol levels have been implicated as attenuating ... but did not increase total sterol concentration. Treatments with empty methyl- -cyclodextrin (M CD) pulled about 20% ...
EurekAlert!2y
lipid droplet formation on endoplasmic reticulum (IMAGE)
But this process only happens in certain microdomains that are rich in sterols and oleosins along the membrane. The Brookhaven team hypothesizes that sterol is essential to the formation of these ...
Nature10mon
Patching the gaps in Hedgehog signalling
The first and often genetically damaged step in this pathway is the interaction between two membrane proteins ... Recent work linking Hh signalling to sterol metabolites and protein-trafficking ...