A giant sarcomere protein titin plays a role in determining the stiffness of myocardium. [17] Titin is expressed in myocardium in two isoforms: N2B (the more rigid form) and N2BA (more compliant).

Edgewise Therapeutics, Inc. , a leading muscle disease biopharmaceutical company, today provided recent corporate updates and highlighted upcoming priorities for 2025. Edgewise Chief Executive Officer ...

The sarcomere is the principal contractile unit of striated muscle. Mutations in genes encoding sarcomeric proteins are responsible for a range of diseases including hypertrophic, dilated and ...

Pulsatile fluid flow generated in the MPS system increased several indicators of maturation such as the beating intensity, sarcomere length ... greatest expression and alignment of contractile ...

The CCs were mainly enriched in sarcomere, myofibril, and contractile fiber ... results highlighted pathways related to the cytoskeleton in muscle cells and motor proteins (Supplementary Figure S3B).

In addition to signaling pathways triggered by extracellular stimuli, a common cause of cardiomyopathy is mutations affecting contractile and structural proteins. The contractile apparatus is ...

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