This month's cover highlights the article Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis by Tobias Ackermann, Saverio Tardito and colleagues. The ...

Centre for Engineering Biology, Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, U.K. Centre for ...

We examined OXPHOS activity by measuring changes in basal and maximal oxygen consumption rate (OCR) following treatment with inhibitors of pyruvate metabolism (UK5099), glutamine metabolism (BPTES), ...

The study explored the influence of magnesium on phenotypic antibiotic resistance in two Vibrio model bacteria. This research is fundamental for revealing the phenotypic antibiotic resistance ...

The authors show that increased pyruvate import into the mitochondria in liver-like cells and in primary hepatocytes drives gluconeogenesis but reduces cellular amino acid production, suppressing ...

Recently, Prof Shen Han-Ming’s team from the National University of Singapore and University of Macau published a research paper titled “Glucose-6-phosphate dehydrogenase regulates mitophagy by ...

Recently, Prof Shen Han-Ming’s team from the National University of Singapore and University of Macau published a research paper titled “Glucose-6-phosphate dehydrogenase regulates mitophagy ...

MMSE, Mini Mental Status Examination; MELAS, mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes; PDH, pyruvate dehydrogenase; α-KGDH, alpha-ketoglutarate dehydrogenase; ATP, ...

This process is facilitated by the inhibition of pyruvate dehydrogenase (PDH) through the action of pyruvate dehydrogenase kinase 1 (PDK1). PDK1 is activated by hypoxia-inducible factor 1 (HIF-1) and ...

The MCU complex is composed of the pore-forming subunit, MCU, its dominant-negative form, MCUb, the essential MCU regulator (EMRE), the mitochondrial Ca 2+ uptake regulatory subunits (MICU1, MICU2, ...