In cell-free protein synthesis ... amino acids that confer altered activity to pinpoint which proteins warrant further study. Another approach is a computer model that uses machine learning ...

Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means for controlling viral infections. An essential prerequisite to their design depends on identifying conserved and ...

Scientists are tapping powerful AI to predict how proteins interact — a tall order even for AI — in the stubborn, fascinating ...

The scientists explained that the billions of protein molecules produced in cells must leave their site of synthesis and arrive ... are consistent with a model in which diverse pathogenic stimuli ...

DNA sequences have no capacity to act on their own but instead express themselves in the form of protein structures and biochemical activities ... they built atomic models of the ribosome-mRNA ...

Tesamorelin, a synthetic peptide analog of growth hormone-releasing hormone (GHRH), has recently garnered attention for its unique biochemical properties and intriguing impact on various physiological ...

ISM5411 is designed to directly regulate the intestinal immune microenvironment so that the drug simultaneously reduces the gut inflammation seen in IBD while also promoting the repair of the ...

Researchers present a new therapeutic tool capable of inhibiting the proliferation of the SARS-CoV-2 virus that causes COVID-19. The results open up new perspectives in the fight against this ...

The Centre for Target Validation is a multidisciplinary research centre which streamlines the connection between biological science and drug discovery.

As a result, while generative models ... activity and synthetic accessibility, demonstrating TamGen’s potential to generate novel candidates for antibiotic development and therapeutic innovation.