The rise of targeted protein degradation (TPD ... POI degradation depends on the Cullin-UPS pathway (MLN-4924/MG-132 rescues degradation). siRNA experiments demonstrated a key functional ...

Kymera Therapeutics is a biotech company with promising candidates in its pipeline for inflammatory disorders. Read why KYMR ...

Selective protein degradation by the ubiquitin–proteasome pathway is a fundamental regulatory strategy that fulfils essential roles in various cellular processes. In recognition of the central ...

Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body ...

We investigate protein degradation processes using chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific ...

mediating the signaling pathways for protein degradation and the maintenance of cellular homeostasis. These proteins act as ...

Study finds ketone esters help clear misfolded proteins in preclinical models of aging and Alzheimer’s disease.

The Würzburg researchers were the first to observe a degradation process directly coupled to protein production ... Unlike ...

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat ...

Fintel reports that on December 10, 2024, BTIG initiated coverage of Kymera Therapeutics (NasdaqGM:KYMR) with a Buy ...