A literature review was performed to collect information on the role of pharmacogenetics in six proposed teratogenic mechanisms associated with drug use during pregnancy: folate antagonism ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...

Professor Julia Stingl will further expand research and consulting on individual and safe drug therapies. To do this, the specialist in clinical pharmacology also uses molecular data that makes it ...

I am greatly looking forward to continuing my role as Chair of the Prix Galien UK Awards Committee, alongside some of the greatest minds at the forefront of global healthcare, said Professor Sir Munir ...

Bioinformatics allowed me to address these questions faster and with a broader perspective. The growing availability of public data facilitated this. However, the transition wasn’t easy. I tried many ...

Improved medical treatments for Emiratis could be the result of a major project researching the genetic variation within the ...

Psychotropic medications are the gold-standard for treating many different psychiatric disorders. Nevertheless, interindividual differences in the efficacy and adverse effects of these medications is ...

The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the ...

Doctors and patient advocates supporting pretreatment testing at times challenged FDA and other experts who aren't swayed by available evidence.

Fluoropyrimidines can quickly build up in patients with DPD deficiencies, increasing toxic exposure. The Clinical Pharmacogenetics Implementation Consortium (CPIC), an internationally recognized ...

Lithium side effects may include diarrhea, rash, hair thinning, weight gain, and more. Lithium is a mood stabilizer used to treat bipolar disorder, a condition that involves episodes of depression, ...

Clopidogrel metabolism and mechanism of action. Clopidogrel is metabolized to its active metabolite by the cytochrome P450 (CYP) 3A enzyme family. The CYP3A gene family is located on chromosome ...