Early treatment of pediatric Crohn's disease with anti-tumor necrosis factor medications can substantially reduce the risk of ...

Perianal fistulas cause significant morbidity and diminish patients' quality of life. Consequences of perianal fistulas include perianal drainage, pain, abscess formation, dyschezia, dyspareunia ...

European regulators have recommended Alofisel, a new advanced therapy to treat complex perianal fistulas in patients with Crohn’s disease. The treatment is now just a step away from being the ...

Odds of complications significantly reduced with early anti-TNFα therapy, especially in those with perianal lesions ...

Early treatment of pediatric Crohn’s disease with anti-tumor necrosis factor medications can substantially reduce the risk of perianal fistulas, a particularly debilitating complication of Crohn ...

Alofisel (darvadstrocel) has been cleared by the Ministry of Health, Labour and Welfare (MHLW) for the treatment of complex perianal fistulas in patients with non-active or mildly active luminal ...

Unfortunately, there are no validated clinical measures of fistulous disease activity. The most comprehensive measure of morbidity caused by perianal Crohn's disease is provided by The Perianal ...

Standard treatment for perianal fistulas involves anti-TNF drugs at higher doses than would be prescribed before complications begin. There's also no guarantee that treatment can completely solve ...