Metastasis is responsible for 90 percent of cancer deaths. Researchers have found that the mutations driving it may stem from a commonly inherited variant of the PCSK9 gene.

In fact, Tavazoie and colleagues had previously demonstrated that various germline alleles of APOE can enhance or suppress melanoma metastasis. To find out whether breast cancer metastasis operates in ...

New research suggests elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves ...

Sohail Tavazoie and Wenbin Mei, a graduate fellow in the Tavazoie lab. (Credit: Lori Chertoff) Metastasis is the cause of 90 ...

When mice are engineered to carry a variant of the human PCSK9 gene, they experience higher rates of breast cancer metastasis ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

It is a basic document for the very existence of the company. Every Company must have its own Memorandum of Association. The MOA is the charter of the company which defines and limitsW the powers of a ...

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union ...

Researchers from the University of California, San Diego, have identified a shared mechanism in the brain that explains how different drugs, such as methamphetamine and PCP (commonly known as “angel ...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein receptor (LDLR) at the surface of hepatocytes and accelerates its degradation in lysosomes, thereby impairing the ...