The latter was then fixed with paraformaldehyde and stained with immunofluorescence ... 2016), which are crucial for neuronal neurite and synaptic regeneration, as well as normal neuronal signal ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aggressive prostate cancer (PCa) variants ...

Sigma 1 receptor (S1R) is a multifunctional, ligand-activated protein located in the membranes of the endoplasmic reticulum (ER). It mediates a variety of neurological disorders, including epilepsy, ...

We hypothesised that neurite orientation dispersion and density imaging (NODDI), a multicompartment model of diffusion MRI, would reveal microstructural changes associated with ALS within the CST and ...

Neurite outgrowth-induced construction of neural circuits and networks is responsible for memory generalization, consolidation, and retrieval. Neurite atrophy and synaptic loss initiate and accelerate ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

1 The presence of vinculin and F-actin was visualized by indirect immunofluorescence with mouse anti-vinculin antibody and by direct staining with rhodamine-phalloidin. The LPA-induced change in ...

Furthermore, we characterized the expression profile of S1PR1 in the hippocampal DG. Immunofluorescence staining results showed that S1PR1 was mostly co-expressed with neuronal nuclear protein (NeuN) ...