Up to a quarter of patients with degenerative mitral valve disease may be asymptomatic despite having severe valve regurgitation. Current guideline indications for intervention in asymptomatic patient ...

It has been generally thought that significant elevations of the left atrial and pulmonary vascular pressures occur in patients with mitral regurgitation of sufficient severity to produce serious ...

Efficient AAV gene delivery to the heart remains a challenge and hinders clinical translation. Here, coronary Stop-flow delivery with mechanical circulatory support dramatically improved gene ...