Scientists are seeking ways to tweak γ-secretase activity to turn down production of Aβ while leaving other substrates untouched. In the January 8 Nature Aging online, researchers led by Jee-Yin Ahn ...

2021; Yamazaki et al., 2019). In late-onset AD, which occurs sporadically after the age of 65, the impairment of amyloid β-protein (Aβ) clearance mechanisms seems to be a primary factor in the ...

Dysbiosis, alterations of the gut microbiota, disorganize the colonic barrier and the BBB, allowing the passage from the periphery to the CNS of proinflammatory factors, immune cells and peptides such ...

kuh.fi Background Single measurements of plasma Aβ are not useful in the diagnostics of Alzheimer's disease (AD). However, changes in plasma Aβ levels during repeated testing may be helpful in the ...