Peroxynitrite induces cell death, and can influence signal-transduction processes, mitochondrial function and signalling of apoptosis. The formation and reactions of peroxynitrite play a ...

Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...

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Excessive mechanical loading downregulates FBXW7 to activate MKK7–JNK signalling, which stimulates chondrocyte senescence and consequently initiates and accelerates OA development. Inhibition of JNK ...

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Creation of all things; creation of Adam and Eve; temptation by Satan; Adam and Eve rebel against God and forfeit Garden of Eden. On that day, Adam and Eve, the father and mother of all mankind, chose ...

In recognising this UK Sport’s approach to funding reflects that journey and works on the basis of an athlete pathway with three clear and distinct levels that make up the World Class Pathway. The two ...

Interestingly, unlike activation through the canonical IgE/FcϵRI pathway, SP/MRGPRB2-mediated degranulation results in the release of more tryptase and less histamine and, subsequently, excites the ...

In 2011 she moved to do her postdoc with Nicolas Tapon at the Cancer Research UK London Research Institute (now The Francis Crick Institute), where she worked on the regulation of tissue growth via ...