The intricate mechanisms behind genetic disorders are reshaping how we understand human disease. Inborn errors of immunity (IEIs), a group of monogenic disorders, exemplify this complexity. These ...
We still have much to learn from monogenic diseases ... monogenic and polygenic inheritance. As monogenic disorders are, overall, mechanistically simpler than complex traits, they offer the ...
Furthermore, the variable features of particular traits can confuse researchers who are attempting to track the inheritance of these conditions. For example, some complex human diseases involve ...
Recent advances in the molecular genetics of PD have markedly improved our conception of its etiology and pathophysiology; however, the identification of different forms of monogenic PD has ...
In contrast, monogenic (mendelian) forms of hypertension are caused by single gene mutations that are influenced little, if at all, by environmental factors. Most monogenic forms of hypertension ...