By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...
Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States ...
which mediate two auto-inhibitory interactions within condensin I. Consistently, the KIF4A SLiM peptide alone is sufficient to stimulate ATPase and DNA loop extrusion activities of condensin I. We ...
Elucidation of protein-protein interactions (PPIs) represents one of the most important methods in biomedical research. Recently, PPIs have started to be exploited for drug discovery purposes and have ...
The vulnerability, which Microsoft has now remediated, put 400 million users of Office 365 at risk of a 2FA bypass attack requiring no user interaction, triggering no alerts and only taking an ...
Scientists say they have recovered the oldest known Homo sapiens DNA from human remains found ... although that interaction did not necessarily happen in the same place. Scientists have known ...
Scientists say they have recovered the oldest known Homo sapiens DNA from human remains found ... although that interaction did not necessarily happen in the same place. Scientists have known ...
Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...
The oldest DNA ever recovered from modern humans shows they arrived as small groups in Europe more than 45,000 years ago and mixed with Neanderthals - but left no descendants. Published today ...
Teen users will now interact with a separate LLM, and the site hopes to "guide the model away from certain responses or interactions, reducing the likelihood of users encountering, or prompting ...
A deeper look at Neanderthal and Denisovan DNA in humans will ultimately help researchers understand the full extent of ancient human migration and genetic interactions.
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