Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across ...

Viracta Therapeutics announced the closure of a phase II trial of its combination therapy of the histone deacetylase ...

Discover recent research that has unveiled the crucial role of Androgen Response Elements in governing androgen receptors ...

Mechanisms that have been characterized in SSc include DNA methylation and histone acetylation and deacetylation. Both DNA methyltransferase inhibitors and HDAC inhibitors have been successfully ...

Here, the authors show that the CPSF6-RARG (CR) fusion interacts with histone deacetylase 3 (HDAC3) to promote myeloid transformation and HDAC inhibitors reduce CR-associated leukemia in ...

Here, the authors show that the CPSF6-RARG (CR) fusion interacts with histone deacetylase 3 (HDAC3) to promote myeloid transformation and HDAC inhibitors reduce CR-associated leukemia in ...

The transcription and protein expression of cTnI were increased, which might be achieved by inhibiting the expression and activity of histone deacetylase 1 (HDAC1), and reducing its binding level ...

Tinostamustine is under clinical development by Northlake International and currently in Phase I for Multiple Myeloma (Kahler Disease).

Purinostat mesylate is under clinical development by Chengdu Zenitar Biomedical Technology and currently in Phase I for Unspecified B-Cell Lymphomas.

Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn institution, An der Immenburg 4, Bonn 53121, Germany ...

Design The effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on the magnitude of the visceromotor response (VMR) to colorectal distention was examined in ...