Long-read, single-molecule DNA sequencing is a foundational method in genomics research, with applications including ...

This study introduces smRandom-seq2, a high-throughput and high-resolution single-microbe RNA sequencing method, which ...

Next-generation sequencing technologies, introduced in the mid-2000s, revolutionized the field of genomics by enabling high-throughput, parallelized sequencing of DNA. NGS methods typically ... and ...

However, this method includes additional steps that permit high-resolution interrogation ... MseI adaptor-associated sequence, the destroyed MseI site, a genomic DNA fragment, the destroyed ...

Arc Institute scientists have engineered a fast, high-resolution ... to predict how small DNA changes affect an organism’s fitness, generate realistic genome-length sequences, and design new ...

Using high-resolution cryo-electron microscopy ... with each piece moving in a precise sequence to achieve DNA supercoiling. Reflecting on the study findings, co-author Professor Jonathan Heddle ...