In a groundbreaking study led by Dr. Ying Chen and her team from Ruijin Hospital, Shanghai Jiao Tong University School of ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

FBXW7 depletion in adipocytes leads to increased lactate production, which in turn impacts glycolysis and brown preadipocyte proliferation in a lactate-dependent way. Next, we constructed FBXW7 ...

Manipulations that curtail lactate generation or impede glycolysis tend to reduce the incidence of Kla, conversely, those that augment lactate production or stimulate glycolysis promote such ...

By thoroughly analyzing GBM glycolysis, this study seeks to ... On the other hand, lactate-induced TME acidification inhibits CD8 T cell proliferation, cytokine production, and cytotoxic function.

To simplify it a ton, lactate is produced as our bodies use glucose to fuel ATP production during glycolysis. Lactate is a fuel source for cells, and it’s accompanied by a hydrogen ion that ...

In HeLa cells, glycolysis and the conversion of pyruvate to lactate are key metabolic pathways for ATP and NADH production. Deletion of MTCH2, however, leads to an increase in mitochondrial oxidative ...

The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...