FTY720 is a structural analogue of sphingosine that, after conversion to the biologically active FTY720-phosphate molecule, binds with high affinity to sphingosine-1-phosphate receptors to act as ...

SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the ...

SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the ...

In addition to cladribine tablets, for which key data are reviewed below, oral therapies undergoing investigation in Phase III studies include: BG12, fingolimod (FTY720), laquinimod (ABR-215062 ...

Fingolimod treatment leads to beneficial effects in Huntington disease (HD), according to a new study in a mouse model of the ...

Toll-like receptors (TLRs) are well-characterized in mice and rats, but little is known on their role in broiler chickens during acute heat stress (AHS). The aim of the present study was to estimate ...