CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

Neuroscientist Robert Love has shared the one simple ingredient he thinks you should add to your morning coffee in order to ...

Fibroblasts are specialized cells in connective tissues that play an important role in wound healing and tissue repair. They produce and organize the so-called extracellular matrix, a network of ...

Human lung fibroblasts stimulated with TGF-β1 to detect extracellular collagen I (pink), alpha-smooth muscle actin (α-SMA) (green), and cell nuclei (blue) as a measure of matrix production and ...

One such cell type, cancer-associated fibroblasts, affects tumor progression in multiple ways, including modifying the stiffness and composition of the extracellular matrix, promoting and ...

adhesion to an extracellular matrix and contraction within the cell body. These events are driven by cycles of activation of Rac1 and RhoA. The appearance of fibronectin in wounded tissue triggers ...

My lab is interested in understanding how the structure of the three-dimensional (3D) extracellular matrix dictates the molecular and physical mechanisms driving cell motility. For example, we ...

Most diabetic wound care products are passive dressings, only providing a protective barrier against the external environment ...

Peptides, as versatile biological molecules, have garnered significant attention in scientific research due to their ...

Quantitative and qualitative changes in matrix protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix Degradation ...