Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries ... Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases ...

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College ...

Dysregulated functions of E3 ubiquitin ligases have been linked to many diseases, including T2DM and NAFLD, making them potential targets for drug development. The potential of developing therapeutic ...

They applied the new method to more than 1,500 European genomes (a person's complete set of DNA) from people who lived primarily during the first millennium AD (year 1 to 1000), encompassing the ...

Americans with European heritage have long been able to pinpoint their ancestry through DNA testing ... That's just a function of who we are as African Americans." About 5% of people who identify ...

Thus, we hypothesized that Dgkζ regulates p53 expression by interacting with cardiac E3 ligases related to Hsp70 and protects cardiomyocytes from apoptosis. This study aimed to examine (1) whether ...