Instead of targeting CDK12, REC-1245 as an RBM39 degrader via E3 ligase adaptor DCAF15 is responsible for interrupting RNA splicing to down-regulate DNA Damage Repair [DDR] network and cell cycle ...

Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries ... either harness or inhibit the natural function of E3 ligases within the ubiquitin ...

This replacement leads to anemia, bleeding, and impaired immune function, while the elevated IgM levels ... Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries ...

The method can illuminate the function of cells and assemble DNA sequencing data into an organism’s genome ... Then we ligate them. The ligase is basically an enzyme that [if] it sees two hanging ends ...

Therefore, the in-depth investigation of the function of E3 ligases and their interactions with other proteins ... including gene transcription and DNA damage repair, thereby might affect the tumor ...

Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how ...

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists at Scripps Research ...

PD-L1 not only responds to the cGAS-STING pathway upon DNA damage, but also regulates cGAS-STING to induce inflammation. This ...

Scientists say they have recovered the oldest known Homo sapiens DNA from human remains found ... Homo sapiens genomes are related to traits and functions that included immune function, skin ...

A groundbreaking study by the Roslin Institute explores how whole genome duplication shaped the complexity and evolution of ...