This study revealed a novel mechanism by which mtDNA 6mA orchestrated mitochondrial function–related gene expression in macrophages, thereby promoting atherosclerosis. Through various experimental ...
kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Accumulation of CD11c + proinflammatory adipose tissue macrophages (ATM) is an important driver of vAT inflammation. We investigated the role of ATMs in hepatic inflammation during NASH development.
AECII, type II alveolar epithelial cell; CCL2, C-C motif chemokine ligand-2; CXCL1, C-X-C motif chemokine ligand-1; GM-CSF, granulocyte-macrophage colony-stimulating factor; G-CSF, granulocyte ...
The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...
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