In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...
Z526- a novel dithiocarbamate-like compound reverses cancer associated cachexia via mitigating NF-B signaling and oxidative ...
Previous studies have suggested that the downregulation of GPX4 and SLC7A11, associated with ferroptosis, is regulated by the AKT/GSK3β signaling pathway. To further verify the upstream target of PFOA ...
Introduction: Pemetrexed is a first line drug for brain metastases from lung cancer, either as monotherapy or combined with other drugs. The frequent occurrence of initial and acquired resistance to ...
LIN treatment decreased the expression of muscle RING-finger protein-1 (MuRF1) and Atrogin1(MAFbx) in muscle, and the activation of insulin-like growth factor-1 (IGF-1)/protein kinase B (Akt)/forkhead ...
Cover picture: Inspired by the Review by Jung-Soon Mo, Hyun Woo Park and Kun-Liang Guan. Illustrated by Sandra Krahl.
Figure. Schematic diagram depicting signaling pathways for regulation of phospho-Ser473-Akt activity cell survival by PHLPP-1. Site-specific dephosphorylation of Ser473-Akt, but not Thr308-Akt by ...
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