Phosphoproteomics unveils the mode of action of clinical ATR inhibitors and explains their synergy with Gemcitabine in ...

Figure. Schematic diagram depicting signaling pathways for regulation of phospho-Ser473-Akt activity cell survival by PHLPP-1. Site-specific dephosphorylation of Ser473-Akt, but not Thr308-Akt by ...

Results: RAGE upon activation by its ligands enhances downstream signaling pathways, contributing to breast cancer cells migration, growth, angiogenesis, metastasis, and drug resistance. In addition, ...

2023). Mechanistically, mitophagy is mainly mediated by two pathways: ubiquitin (Ub)-dependent pathway and Ub-independent pathway. Figure 3. Schematic diagram of Ub-dependent mitophagy (up) and ...