Lactylation is a reversible, covalent, post-translational modification of proteins. It occurs exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

Researchers at University of Tsukuba identified a previously unconfirmed gas exchange threshold in rats and demonstrated that ...

Then, the role of aerobic glycolysis in IL-1β production was evaluated, as well in vitro as in vivo using 18 F-fluorodeoxyglucose positron emission tomography imaging and glucose uptake assay, and ...

Mammalian cells can also generate D-lactate during methylglyoxal metabolism. Methylglyoxal is mainly produced as a byproduct of glycolysis, although it can also be produced during lipid peroxidation ...

Therefore, exploring these factors and the cross-conversion between glycolysis and mitochondrial activity in various cells in the tumor microenvironment is essential for understanding the metabolic ...

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for ...

Understanding the impact of aerobic power on sustainable speed, the role of lactate tolerance in performance, and the concept of fallback pace as a measure of aerobic conditioning are also crucial ...

Recent findings about the new roles of lactate have changed our understanding of this end product of glycolysis or fermentation that was once considered only a waste product. It is now well accepted ...