RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns, splicing ...

Collectively, these results demonstrate that TSSC4 deficiency leads to aberrant alternative splicing and increased expression of oncogenes, further supporting the role of TSSC4 as a tumor suppressor.

Aberrant immune responses are a hallmark of ageing and age ... These are likely to include miRNA sponging, splicing regulation and scaffolding for the assembly of macromolecular complexes (such as ...

Indeed, most Mendelian disorders are caused by exonic mutations or splice-site mutations that change the amino ... mutations in acute myeloid leukaemia (AML) may imply that aberrant epigenetic ...

Lamin B1 expression was reduced in all colon cancers, 16/18 colonic adenomas, and 6/8 gastric cancers. Aberrant, cytoplasmic labelling with both antibodies occurred in some colonic cancers and around ...

This important study addresses how 3' splice site choice is modulated by the conserved spliceosome-associated protein Fyv6. The authors provide compelling evidence that Fyv6 functions to enable ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The analysis of protein-bound glycans has gained significant attention due to their ...

Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, United States Hearing loss can profoundly impact an individual’s quality ...

Ductal carcinoma in situ (DCIS) is the most common type (80%) of non-invasive breast lesions in women. The lack of validated prognostic markers, limited patient numbers, and variable tissue quality ...