Post-translational modifications are modifications that occur on a protein, catalysed by enzymes, after its translation by ribosomes is complete. Post-translational modification generally refers ...

Post-translational modifications (PTMs) are chemical changes to proteins that follow their synthesis and secretion. These modifications play a crucial role ...

Similarities to the post-translational modification phosphorylation suggest that AMPylation may be an important regulatory mechanism. Post-translational modifications are key steps in the ...

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer ...

These studies revealed structural determinants for recognition of consensus SUMO modification sequences found within SUMO conjugated proteins. Reconstituting SUMO conjugation in vitro revealed ...

Humans possess potentially millions of protein variants (proteoforms), derived through mechanisms including post-translational modifications. This has made protein sequencing more complicated than ...

For modern biotherapeutics, cell line development workflows must include more than just automated liquid handling.

As a shared facility of the Bindley Bioscience Center (BBC) in Discovery Park of Purdue University, the facility enables both targeted and global analysis of proteins, their post-translational ...

We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like ...

Membrane proteins are key targets for therapeutic intervention using antibody biologics. Over 60% of FDA-approved drugs act ...

Glycosylation is one of the most common post-translational modifications of proteins and plays major roles in various aspects of cellular and organismal biology. We use Drosophila and mouse genetics ...