causing the hallmark elevated Phe levels observed in PKU. "Based on tRNA's critical role in protein translation, a single tRNA medicine is uniquely positioned to address multiple diseases that ...

For example, the amino acid phenylalanine (Phe) is specified by the codons UUU ... Next, the specific tRNA molecule that carries methionine recognizes this codon and binds to it (Figure 5).

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Alltrna unlocks tRNA biology to correct disease ... restoration resulted in a meaningful 76% reduction of phenylalanine (Phe) levels from baseline, as PAH is the enzyme responsible for breaking ...