We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

Researchers at McMaster University, Canada, have identified a critical biological mechanism involving the protein MANF ...

The Cullin family proteins have been shown to act as internal components of the ubiquitin-proteasome system, mediating the ...

databases—gives the reader a real sense of the complexity of the ubiquitin system. I particularly enjoyed Martin Rechsteiner's review of the biology of the 26S proteasome and appreciate his ...

The AD connection? SIRT6 deacetylates three adjacent lysines in amyloid precursor protein, and this post-translational modification offers APP up to the ubiquitin-proteasome system for degradation. As ...

The new agreement will tap into Cullgen’s targeted protein degradation platform – called uSMITE – which focuses on the ubiquitin proteasome system and, specifically, ligands for E3 ligases ...

Our team is focused on study the function of Ubiquitin Proteasome System (UPS) components in Arabidopsis growth and development as well as in responses to environmental challenges. Our team is also in ...

Alfa Chemistry is one of the leading chemical manufacturers and suppliers who has been able to maintain its leadership position in the pharmaceutical sector by offering a broad product portfolio that ...

Proteolysis-targeting chimera (PROTAC) is a revolution in protein degradation. PROTACs take over the ubiquitin-proteasome system to degrade pathogenic proteins. They're complex molecules made up of an ...