The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...

Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...

suitably small size (<30 nm) and active targeting features demonstrate great potential for siRNA delivery. Lipid nanoparticle-based siRNA delivery enables us to fulfill the vision of personalized ...