A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the ...

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease.

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

leading to the transcription of genes encoding chaperones and many components of the secretory pathway, and through a parallel process suppresses protein synthesis by modulating the ...

10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking of glycoproteins through the secretory pathway. When attached to target proteins, this sequence ...