Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

However, recent studies have identified promising small molecules that can modulate the activity of myosin, a key protein in the cardiac sarcomere. For instance, drugs like mavacamten and ...