Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

Her research is focused on the mechanism of sarcomere proteins in heart muscle contraction. She aims to understand how troponin, specifically troponin I (TnI), contributes to the dynamic thin filament ...

A giant sarcomere protein titin plays a role in determining the stiffness of myocardium. [17] Titin is expressed in myocardium in two isoforms: N2B (the more rigid form) and N2BA (more compliant).