New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases ... β-catenin, focal adhesion kinase) and proteins involved in signalling pathways, in apoptosis regulation ...

Small GTPases of the Rho family are potent modulators of the ... together with the Ser/Thr kinase atypical protein kinase C (aPKC), constitute the PAR complex (see figure). Isoforms of PAR-3 ...

Valo Health’s Rho kinase (ROCK) 1 and 2 inhibitor has failed to reduce the severity of diabetic retinopathy in a phase 2 trial, leading the Flagship-founded biotech to drop the candidate.

Autosomal dominant missense mutations that hyperactivate the LRRK2 protein kinase are a common cause of inherited Parkinson ... that has revealed that LRRK2 phosphorylates a subset of Rab GTPases ...