However, current protocols for isolating nuclei from complex tissues typically include labor-intensive ... including easy and automated nuclei extraction and isolation for reproducible single-nucleus ...

Their study challenges the status quo, revealing a new role for nuclei in the control of tissue organization and mechanics. To explore how the size of the cell's nucleus affects organ formation ...

Consequently, the need to dissociate all types of solid tissues into single-cell suspensions, and isolate target cells and nuclei has grown. Starting experiments with a fully dissociated, debris-free, ...