Boosting NMDA receptor functioning through various drugs has become an important therapeutic strategy in preventing neurotoxicity associated with receptor hypofunctioning. For example, drugs that ...

There are now ketamine clinics nationwide where the drug is given intravenously to treat depression. Like a lock and key, ketamine binds to the brain via N-methyl-D-aspartate (NMDA) receptors.

Relmada Therapeutics said Wednesday morning that a Phase 3 study testing its major depression drug, REL-1017, is likely to ...

Relmada halted Phase 3 trials of NMDA receptor blocker for depression but will continue its early psilocybin program while ...

The study is led by the university’s psychiatry, psychology, and clinical and translational science associate professor Dr ...

Apimostinel has a similar mode of action to ketamine and derivatives like Johnson & Johnson's Spravato (esketamine) – ...

emphasizes the importance of this type of research due to the role of NMDA receptors in current Alzheimer's treatments, as memantine, one of the most commonly used drugs for the disease ...

NMDA antagonist dextromethorphan is an ingredient ... than current tricyclic or selective serotonin reuptake inhibitor drugs can take weeks to elevate mood, placing severely affected patients ...

Pregnancy. Nursing mothers. Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ ...

Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine ...

Relmada Therapeutics will halt two Phase III trials of a major depressive disorder drug after a futility assessment and ...

or NMDA (1 mM) was applied in a background of 100 μM glycine using a fast microperfusion system. Unless otherwise noted, 5-s applications were delivered every 120 s, and drugs were added to the ...