pulmonologyadvisor5h
COPD Triple Therapy vs LABA/LAMA May Increase Risk for Pneumonia, Death
Patients with COPD who switched to LABA/LAMA/ICS vs LABA/LAMA after previously using LABA/ICS had a higher risk for severe pneumonia and death.
pharmaphorum3y
Cerevel soars on first data for muscarinic schizophrenia drug
an already-approved muscarinic antagonist designed to reduce M1/M4-related side effects in the peripheral nervous system. Meanwhile, Sosei Heptares also has a selective M4 agonist in early-stage ...
pharmaphorum1y
FDA kicks off review of Karuna’s schizophrenia drug KarXT
which combines muscarinic agonist xanomeline tartrate and muscarinic antagonist trospium chloride, as a treatment for adults with schizophrenia - a condition that affects around 3.9 million people ...
Nature5y
Tuning muscarinic receptor signalling
The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...
The Financial Express11d
Cobenfy set to break dopamine dominance in schizophrenia treatment
According to GlobalData’s Drugs Database, the schizophrenia market remains dominated by dopamine-targeted mechanisms, such as ...