Check with the cruise line before booking. Here's a list of the best Mississippi River cruise itineraries you can book in 2025. Find your perfect cruise American Cruise Lines operates a 24-vessel ...

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The second riverboat is the sister-ship to state-of-the-art American Song, the first modern riverboat available in the U.S., which will make its inaugural cruise on the Mississippi River this October.

The Mississippi River looms large in the American psyche. Long before trains, planes and automobiles, Native people — and later fur traders, rum runners, colonists and goods — traversed the ...

American Cruise Lines' "Great United States" itinerary ... the American Serenade for a nearly three-week-long voyage on the Mississippi River. Along the way, the ship will call at such ports ...

As the leading river cruise company in the U.S., American Cruise Lines has taken its small ship expertise to the East Coast inland waterways, Mississippi, Cumberland, Tennessee and Ohio Rivers, ...

Cruise Critic is not a booking agent and does not charge any service fees to users of our site. Our partners who list cruise pricing on Cruise Critic are required to provide prices for cruise only ...